Jun 29, 2020
Fourth COVID-19 study available
66.9 M annotated sequences from Liao et al. "Single-cell Landscape of Bronchoalveolar Immune Cells in Patients With COVID-19" now available through the iReceptor Gateway.
Jun 22, 2020
Third COVID-19 study available
3.7 M annotated sequences from Galson et al. "Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures" now available.
Jun 15, 2020
Second COVID-19 study available
87 million annotated sequences from the pre-press paper Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection from Minervina, et al. have been added.
Jun 04, 2020
iReceptor upgraded to v3.0 - COVID-19 data available! The iReceptor v3.0 upgrade implements the recently released AIRR v1.3 standard. All repositories in the iReceptor Public Archive have been upgraded.We are also pleased to announce the addition of the AIRR COVID-19 repository, with our first AIRR-seq COVID-19 data set.Jun 04, 2020
Downtime noticeThe iReceptor Gateway will be down for maintenance and a platform upgrade on June 4, 2020 from 11:00 - 15:00 Pacific time. Sorry for the inconvenience...
Mar 27, 2020
AIRR Community calls for public sharing of COVID-19 dataThe AIRR Community recently made a public call for the sharing of AIRR-seq data. In their call they state "... the AIRR-C hereby calls upon its members, and the wider research community, to share experiences, resources, samples, and data as openly and freely as possible, and to work within their respective systems to break down barriers to achieve this goal, subject to the overarching directives of respect, privacy, and protection for patients and all people. We are in this together."
Mar 18, 2020
iReceptor Gateway and Repositories down 08:50 - 10:45 Pacific, Mar 18, 2020
Our service provider Compute Canada had a network outage that made the iReceptor services unavailable during this time. All service are now back on line.
Feb 06, 2020
IPA maintenance Feb 6, 2020 completed.
A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. All services are now back online.
Feb 06, 2020
IPA maintenance required - Feb 6, 2020.
A maintenance outage was required for one of the iReceptor Public Archive repositories from 7:30 AM - 8:30 AM Pacific Time, Feb 6, 2020. During this period 400M rearrangements were not available. Searches on other IPA and external repositories were not affected.
Dec 20, 2019
Scheduled Maintenance Jan 8, 2020.
On Wednesday, January 8, external network access to the iReceptor service provider (Compute Canada) will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 7:00 pm to 8:00 pm (PST) / 10:00 pm to 11:00 pm (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.
Nov 25, 2019
Scheduled Maintenance Dec 4, 2019.
On Wednesday, December 4, external network access to the iReceptor service provider (Compute Canada) will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 to 10:00 pm (PST) / 10:00 pm to 1:00 am (EST). There will be no access to the iReceptor Gateway and the iReceptor Public Archive repositories during this outage.
Nov 19, 2019
Update Nov 20, 2019: The issue has been resolved and the sequences are available again.
Nov 19, 2019 - 389 million sequences are unavailable
389 million sequences are currently unavailable because of a technical problem with the iReceptor Public Archive. We expect the situation to be resolved over the next few days.
Oct 02, 2019
2019-09-03: iReceptor reaches 2 Billion annotated sequences
463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive
Sep 13, 2019
Scheduled maintenance: Sep 25, 7:00 - 10:00 pm (PDT)External network access to our service provider, Compute Canada, will be interrupted for at least 1 hour during a 3-hour network maintenance window from 7:00 - 10:00 pm (PDT) / 10:00 pm - 1:00 am (EDT). The iReceptor Gateway and the iReceptor Public Archive repositories will be unavailable at this time.
Sep 04, 2019
2018-03-09: iReceptor reaches 2 Billion annotated sequences
463M annotated sequences added from two new studies: Vergani, et al. (37M) "Novel Method for High-Throughput Full-Length IGHV-D-J Sequencing of the Immune Repertoire from Bulk B-Cells with Single-Cell Resolution" and Pogorelyy, et al. (426M) "Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins" were added to the iReceptor Public Archive
Aug 09, 2019
Scheduled IPA maintenance complete
2019-08-03 13:30 PDT: Maintenance has been completed, all services and repositories are back on line!
Aug 08, 2019
Scheduled IPA maintenance: August 8, 10:00-12:00 PDT
We are making an important code update which will make some of the repositories unavailable during this time period. Searches performed during this time will not search the entire AIRR Data Commons.
Update: Maintenance is taking slightly longer than expected, we expect to be back by 13:00 PDT
Jul 29, 2019
181M annotated sequences back on line
Internal query optimizations that were causing issues (reported 2019-07-03) have been fixed. 181M annotated sequences from the studies that were taken offline on 2019-07-03 are now back online. For more information see the iReceptor Public Archive Data Provenance page
Jul 03, 2019
181M annotated sequences temporarily removed
An error in an internal optimization mechanism on the iReceptor repository has been discovered that resulted in incorrect V/D/J gene searches on two studies from 2019-06-21 to 2019-07-03. The problem will be fixed and the data will be back in production soon. For more information see the iReceptor Public Archive Data Provenance page
Jun 26, 2019
June 26 maintenance finished
The Tapis (AGAVE) authentication service maintenance is finished, the iReceptor Gateway is back on line.
Jun 25, 2019
Scheduled outage on June 26
This Wednesday, from 6am to 3pm Pacific Time, our authentication service provider Tapis (formerly Agave), will undergo maintenance. It won't be possible to log in to the iReceptor Gateway during that time.
Jun 21, 2019
154M annotated sequences added
Data from two new studies: Sims, et al. "Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire." and Jia, et al. "Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer."
Jun 21, 2019
27M annotated sequences added
27M annotated sequences added from Stern, et al. "B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes" added to the iReceptor Public Archive.
Jun 19, 2019
IPA maintenance: June 19, 15:20-17:00 PDT
On Wednesday, June 19, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were unavailable during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.
Jun 14, 2019
IPA maintenance: June 14, 15:00-17:00 PDT
On Thursday, June 14, maintenance was required on several of the iReceptor Public Archive repositories. Two of the four repositories were down for 30 minutes each during this time period. Any searches performed during this time would have not have searched the entire AIRR Data Commons.
Jun 03, 2019
Scheduled outage: June 13, 20:00-21:00 PDT
On Thursday, June 13, external network access to our service provider, Compute Canada, will be interrupted for up to 30 minutes during a 1-hour network maintenance window from 8:00 p.m. to 9:00 p.m. (PDT). During this time the iReceptor Gateway and the IPA repository will be unavailable.
May 06, 2019
AIRR Community Meeting - May 10 to 15
The iReceptor Team is looking forward to seeing colleagues at the AIRR Community meeting in Genoa to talk about sharing AIRR-seq data!
Apr 30, 2019
April 30, 2019 - iReceptor Public Archive back online
The technical problems we experienced from Apr 22 - Apr 30 have been resolved. Our 1.3B sequence annotations are back!
Apr 26, 2019
Apr 22, 2019 - iReceptor Public Archive offline
We are currently experiencing technical issues with the file system from our service provider. All repositories are currently disabled until this issue has been fixed.
We expect to be fully back on line Apr 30, PM Pacific time.
Mar 22, 2019
March 22, 2019 - 200M annotated sequences added
Data from three new studies of tumour-infiltrating lymphocytes in oesophageal squamous cell carcinoma, glioblastoma, and primary liver carcinoma have been added. More information on these studies is available on the iReceptor website.
Jan 24, 2019
2019-01-24: 452M annotated sequences added
Data from Zvyagin et. al. "Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children" added to the iReceptor Public Archive. Over 1 Billion annotated sequences now available!Nov 28, 2018
2018-11-27: Data download limit removed
The data download limit of 500,000 sequence annotations has now been removed. Users are able to download large data sets, with the current limit now a 24 hour time limit! Note that large downloads may take a long time, with download speeds ranging from 3M to 90M sequence annotations/hour.
Oct 17, 2018
2018-10-17: 312M annotated sequences added
Data from Wang et. al. "The Different T-cell Receptor Repertoires in Breast Cancer Tumors, Draining Lymph Nodes, and Adjacent Tissues" added to the iReceptor Public Archive.
Jul 06, 2018
2018-07-12: iReceptor version 2.0 is now available
Both the iReceptor Public Archive (IPA) (Simon Fraser University/Compute Canada) and VDJServer (University of Texas Southwestern Medical School) repositories are available.
Jun 01, 2018
2018-06-01: iReceptor version 2.0 is now available.
Only a single study is accessible at this time, but we expect the iReceptor Public Archive (Victoria) and VDJServer (Texas) repositories to support the v2.0 Gateway at the end of June.